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[view Contraindications (4)] Zanaflex needs to be used with care in clients with renal lack (creatinine clearance < 25 mL/min), as clearance is lowered by more than 50 %. As a result of possible drug communications, concomitant usage of Zanaflex with other CYP1A2 preventions, such as zileuton, fluoroquinolones besides solid CYP1A2 inhibitors (which are contraindicated), antiarrythmics (amiodarone, propafenone, verapamil, as well as mexiletine), cimetidine, famotidine, contraceptive pills, acyclovir, as well as ticlopidine) should be stayed clear of.
After making any adjustments in exactly how you take tizanidine, call your doctor if you see any kind of adjustment in exactly how well the medication works or if it creates increased negative effects. The average dosage throughout the plateau stage ranged from 20-- 28 mg/day.